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PF-06928215

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Chemical Structure| 2378173-15-8 同义名 : -
CAS号 : 2378173-15-8
货号 : A897530
分子式 : C20H20N4O4
纯度 : 98%
分子量 : 380.397
MDL号 : MFCD31697699
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:1个月-80°C:12个月
溶解度 :

DMSO: 35 mg/mL(92.01 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Cyclic GMP-AMP synthase (cGAS) is the primary sensor in innate immune activation in response to cytosolic dsDNA. PF-06928215 is a cGAS inhibitor with an IC50 value of 4.9μM. It shows a binding affinity of 0.2μM in the cGAS assay.[2]
作用机制 PF-06928215 is a high-affinity cGAS inhibitor.[2]
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.63mL

0.53mL

0.26mL

13.14mL

2.63mL

1.31mL

26.29mL

5.26mL

2.63mL
参考文献

[1]Hall J, Brault A, Vincent F, et al. Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay. PLoS One. 2017;12(9):e0184843.

[2]Hall J, Brault A, Vincent F, Weng S, Wang H, Dumlao D, Aulabaugh A, Aivazian D, Castro D, Chen M, Culp J, Dower K, Gardner J, Hawrylik S, Golenbock D, Hepworth D, Horn M, Jones L, Jones P, Latz E, Li J, Lin LL, Lin W, Lin D, Lovering F, Niljanskul N, Nistler R, Pierce B, Plotnikova O, Schmitt D, Shanker S, Smith J, Snyder W, Subashi T, Trujillo J, Tyminski E, Wang G, Wong J, Lefker B, Dakin L, Leach K. Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay. PLoS One. 2017 Sep 21;12(9):e0184843. doi: 10.1371/journal.pone.0184843