产品说明书

Entacapone sodium salt

Print
Chemical Structure| 1047659-02-8 同义名 : Entacapone Sodium
CAS号 : 1047659-02-8
货号 : A891824
分子式 : C14H14N3NaO5
纯度 : 98%
分子量 : 327.268
MDL号 : MFCD28346924
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Entacapone sodium salt is an effective, reversible, peripherally active, and orally administered catechol-O-methyltransferase (COMT) inhibitor. It inhibits COMT in rat brain, erythrocytes, and liver with IC50 values of 10 nM, 20 nM, and 160 nM, respectively. Entacapone sodium salt selectively inhibits COMT over other catecholamine metabolizing enzymes such as MAO-A, MAO-B, phenolsulphotransferase M (PST-M), and PST-P, all with IC50 values greater than 50 µM, and is used in Parkinson's disease research[1]. Entacapone sodium salt acts as an inhibitor of FTO demethylation with an IC50 of 3.5 μM and is utilized in metabolic disorder studies[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.06mL

0.61mL

0.31mL

15.28mL

3.06mL

1.53mL

30.56mL

6.11mL

3.06mL
参考文献

[1]E Nissinen, et al. Biochemical and pharmacological properties of a peripherally acting catechol-O-methyltransferase inhibitor Entacapone sodium salt . Naunyn Schmiedebergs Arch Pharmacol. 1992 Sep;346(3):262-6.

[2]Shiming Peng, et al. Identification of Entacapone sodium salt as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1. Sci Transl Med