产品说明书

PF-04991532

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Chemical Structure| 1215197-37-7 同义名 : -
CAS号 : 1215197-37-7
货号 : A891536
分子式 : C18H19F3N4O3
纯度 : 98%
分子量 : 396.364
MDL号 : MFCD27938256
存储条件:

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 120 mg/mL(302.75 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 PF-04991532 is a potent, hepatoselective glucokinase activator with EC50s of 80 and 100 nM in human and rat, respectively.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01369602 Type 2 Diabetes Mellitus ... 展开 >> Healthy 收起 << Phase 1 Completed - United States, California ... 展开 >> Pfizer Investigational Site Anaheim, California, United States, 92801 United States, Florida Pfizer Investigational Site DeLand, Florida, United States, 32720 收起 <<
NCT01338870 Diabetes Mellitus, Type 2 Phase 2 Completed - -
NCT01388829 Healthy Phase 1 Completed - United States, Connecticut ... 展开 >> Pfizer Investigational Site New Haven, Connecticut, United States, 06511 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.52mL

0.50mL

0.25mL

12.61mL

2.52mL

1.26mL

25.23mL

5.05mL

2.52mL