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(2R)-Octyl-α-hydroxyglutarate

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Chemical Structure| 1391194-67-4 同义名 : (2R)-Octyl-2-HG
CAS号 : 1391194-67-4
货号 : A888839
分子式 : C13H24O5
纯度 : 97%
分子量 : 260.327
MDL号 : MFCD30735809
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(403.34 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 (2R)-Octyl-α-hydroxyglutarate is a modified form of 2-Hydroxyglutarate with high cellular uptake. Treatment of IDH1-WT HeLa cells with (2R)-Octyl-α-hydroxyglutarate leads to an increase in DSBs in log phase cells in a dose-dependent manner. It has been used to study the contribution of D-2-hydroxyglutarate to mitochondrial oxidative processes in IDH1 mutant cancer cells[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.84mL

0.77mL

0.38mL

19.21mL

3.84mL

1.92mL

38.41mL

7.68mL

3.84mL
参考文献

[1]Sulkowski PL, et al. 2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologousrecombination and induces PARP inhibitor sensitivity. Sci Transl Med. 2017 Feb 1;9(375).