S55746
产品说明书
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同义名 : | BCL201 |
| CAS号 : | 1448584-12-0 | |
| 货号 : | A887253 | |
| 分子式 : | C43H42N4O6 | |
| 纯度 : | 99% | |
| 分子量 : | 710.817 | |
| MDL号 : | MFCD31715456 | |
| 存储条件： |
粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 50 mg/mL(70.34 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | S55746 is a potent, orally active and selective BCL-2 inhibitor with a Ki of 1.3 nM and a Kd of 3.9 nM. S55746 is effective in selectively inducing cell death through inhibition of BCL-2 in a BAX/BAK-dependent manner at a concentration of 1 μM[1]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT02603445 | Follicular Lymphoma, Mantle Ce... 展开 >>ll Lymphoma 收起 << | Phase 1 | Completed | - | United States, New York ... 展开 >> Novartis Investigative Site New York, New York, United States, 10017 United States, Texas Novartis Investigative Site Houston, Texas, United States, 77030 Austria Novartis Investigative Site Salzburg, Austria, 5020 France Novartis Investigative Site Pierre-Benite Cedex, France, 69495 Novartis Investigative Site Toulouse Cedex 9, France, 31059 Germany Novartis Investigative Site Freiburg, Germany, 79106 Novartis Investigative Site Mainz, Germany, 55131 收起 << |
| NCT02920697 | Chronic Lymphocytic Leukaemia ... 展开 >>(CLL) B-Cell Non-Hodgkin Lymphoma (NHL) Multiple Myeloma (MM) 收起 << | Phase 1 | Completed | - | Australia ... 展开 >> The Alfred Hospital Malignant Haematology & Stem Cell Transplantation Services Melbourne, Australia, 3004 France Hopital Claude Huriez Lille, France CHU de Nantes Nantes, France Centre hospitalier Lyon Sud Pierre-Bénite, France Gustave Roussy Villejuif, France Germany Universitätsklinikum Carl Gustav Carus Dresden, Germany Städtisches Klinikum Schwabing Munich, Germany Universitätsklinikum Ulm Ulm, Germany Hungary National Oncology Institute Budapest, Hungary CRU Hungary Kft Miskolc, Hungary Korea, Republic of Severance Hospital Seoul, Korea, Republic of St. Mary's Hospital Seoul, Korea, Republic of Poland Warsaw Institute of Oncology Warsaw, Poland Warsaw Medical University Warsaw, Poland Singapore National Cancer Center (NCC) Singapore, Singapore National University Cancer Institute Singapore Singapore, Singapore United Kingdom University College London Hospitals London, United Kingdom Freeman Hospital Newcastle, United Kingdom 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.41mL 0.28mL 0.14mL |
7.03mL 1.41mL 0.70mL |
14.07mL 2.81mL 1.41mL |
| 参考文献 |
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