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Chrysophanol-8-O-β-D-glucopyranoside

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Chemical Structure| 13241-28-6 同义名 : Chrysophanol 8-O-glucoside;Pulmatin
CAS号 : 13241-28-6
货号 : A886470
分子式 : C21H20O9
纯度 : 98%
分子量 : 416.378
MDL号 : MFCD20260508
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(120.08 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Chrysophanol 8-O-glucoside, a natural product isolated and purified from the roots of Rheum with potent inhibitory effect on collagen- and thrombin-induced platelet aggregation, only inhibits platelet phosphatidylserine exposure, but not exerts direct inhibition on intrinsic factors, suggests that it may be of therapeutic benefit for the prevention of platelet-related cardiovascular diseases. It has mild cytotoxicity and anti-diabetic properties and can play metabolic roles in the insulin-stimulated glucose transport pathway, and exhibits significant anti-HBV activities with improved liver function.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.40mL

0.48mL

0.24mL

12.01mL

2.40mL

1.20mL

24.02mL

4.80mL

2.40mL
参考文献

[1]Wang Z, Ma P, et al. Evaluation of the content variation of anthraquinone glycosides in rhubarb by UPLC-PDA. Chem Cent J. 2013 Oct 26;7(1):170.

[2]Seo EJ, Ngoc TM, et al. Chrysophanol-8-O-glucoside, an anthraquinone derivative in rhubarb, has antiplatelet and anticoagulant activities. J Pharmacol Sci. 2012;118(2):245-54.