产品说明书

Autophinib

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Chemical Structure| 1644443-47-9 同义名 : -
CAS号 : 1644443-47-9
货号 : A886466
分子式 : C14H11ClN6O3
纯度 : 97%
分子量 : 346.728
MDL号 : MFCD31560472
存储条件：

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 5 mg/mL(14.42 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • Vps34

    Vps34, IC50:19 nM

  • Autophagy

    Autophagy, IC50:40 nM
描述 Autophinib inhibits the accumulation of autophagosomes under fed as well as starved conditions, but does not affect the number of autolysosomes. Thus it is not a late stage autophagy inhibitor but an inhibitor of autophagosome formation. Autophinib targets VPS34 but not other lipid kinases, mTOR and TBK1. Autophinib appears to be ATP-competitive, targets VPS34 in cell lysate and induces cellular phenotypes consistent with VPS34 inhibition.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.88mL

0.58mL

0.29mL

14.42mL

2.88mL

1.44mL

28.84mL

5.77mL

2.88mL