产品说明书
Piperacillin sodium
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同义名 : | Sodium piperacillin;Piperacillin (sodium salt);Piperacillin curasan;Piperacillin;Pipera-hameln;Hexal Brand of Piperacillin Sodium;Fresenius Brand of Piperacillin Sodium;curasan Brand of Piperacillin Sodium;Piperacillin (sodium);Pipracil;PIPERACILLIN SODIUM SALT;T-1220;CL 227,193 |
| CAS号 : | 59703-84-3 | |
| 货号 : | A881033 | |
| 分子式 : | C23H26N5NaO7S | |
| 纯度 : | 98+% | |
| 分子量 : | 539.537 | |
| MDL号 : | MFCD00917471 | |
| 存储条件： |
粉末 Inert atmosphere,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(194.61 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 100 mg/mL(185.34 mM) |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Piperacillin sodium is a broad-spectrum β-lactam antibiotic[2]. At a concentration of 0. 1 mg/mL, piperacillin inhibited all streptococci except enterococci. At 25 mg/mL, piperacillin inhibited 95% of Pseudomonas aeruginosa and 78% of Bacteroides fragilis. Synergistic activity of piperacillin was demonstrated when it was combined with amikacin, gentamicin, and cefazolin against P. aeruginosa and members of the Enterobacteriaceae[3]. In addition, piperacillin causes mitochondrial dysfunction in neuron cells as shown by the reduction of mitochondrial respiration, membrane potential, and ATP production[4]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT00435305 | - | Terminated(difficulties by enr... 展开 >>olling patients fundings consumed, no staff could be recruited and payed to continue enrolling patients,) 收起 << | November 2007 | Germany ... 展开 >> Universitäsklinikum Tübingen, Klinik für Anästhesiologie und Intensivmedizin Tübingen, Germany, 72076 收起 << | |
| NCT01667094 | Cystic Fibrosis | Phase 4 | Active, not recruiting | July 2017 | Australia, Victoria ... 展开 >> The Alfred Hospital Melbourne, Victoria, Australia, 3181 收起 << |
| NCT01066013 | Infections | Not Applicable | Unknown | June 2010 | - |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
1.85mL 0.37mL 0.19mL |
9.27mL 1.85mL 0.93mL |
18.53mL 3.71mL 1.85mL |
| 参考文献 |
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