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ITSA-1

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Chemical Structure| 200626-61-5 同义名 : -
CAS号 : 200626-61-5
货号 : A879167
分子式 : C13H7Cl2N3O
纯度 : 99+%
分子量 : 292.12
MDL号 : MFCD00195103
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(102.7 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 ITSA-1 acts as HDAC activator and counteracts the effects of trichostatin A on cell cycle arrest, histone acetylation, and transcriptional activation. Treatment with ITSA-1 at a concentration of 50 μM in A549 cells helps restore the TSA-arrested cell population to a normal cell cycle distribution and is capable of maintaining cell cycle rescue over extended periods. Additionally, a 50 μM ITSA-1 treatment for 5 hours in A549 cells decreases apoptosis in cells treated with TSA. When applied to A549 and murine ES cells for 2 hours, ITSA-1 at the same concentration suppresses TSA-induced histone acetylation, with the suppression effect only noticeable when ITSA-1 is administered simultaneously with or after TSA treatment. Furthermore, a 30-minute treatment with ITSA-1 at 50 μM in murine ES cells inhibits TSA-induced transcription[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.42mL

0.68mL

0.34mL

17.12mL

3.42mL

1.71mL

34.23mL

6.85mL

3.42mL
参考文献

[1]Koeller KM et al. Chemical genetic modifier screens: small molecule trichostatin suppressors as probes of intracellular histoneand tubulin acetylation. Chem Biol. 2003 May;10(5):397-410.

[2]Behera J, et al. Hydrogen Sulfide Promotes Bone Homeostasis by Balancing Inflammatory Cytokine Signaling in CBS-Deficient Mice through an Epigenetic Mechanism. Sci Rep. 2018 Oct 15;8(1):15226.