Bosentan
产品说明书
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同义名 : | Ro 47-0203 |
| CAS号 : | 147536-97-8 | |
| 货号 : | A876581 | |
| 分子式 : | C27H29N5O6S | |
| 纯度 : | 98% | |
| 分子量 : | 551.614 | |
| MDL号 : | MFCD00867375 | |
| 存储条件： |
Pure form Sealed in dry,Store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(190.35 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Bosentan is an endothelin (ET) receptor antagonist for ET-A and ET-B with Ki of 4.7 nM and 95 nM, respectively. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT00080457 | Pulmonary Hypertension | Phase 3 | Completed | - | United States, Texas ... 展开 >> Encysive Pharmaceuticals Houston, Texas, United States, 77401 收起 << |
| NCT00302211 | Pulmonary Hypertension | Phase 3 | Terminated(Terminated due to s... 展开 >>low enrollment) 收起 << | - | - |
| NCT00266903 | - | Completed | - | United States, Georgia ... 展开 >> Children's Healthcare of Atlanta Atlanta, Georgia, United States, 30322 收起 << | |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
1.81mL 0.36mL 0.18mL |
9.06mL 1.81mL 0.91mL |
18.13mL 3.63mL 1.81mL |
| 参考文献 |
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