DAAO inhibitor-1

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Chemical Structure| 2065250-25-9 同义名 : -
CAS号 : 2065250-25-9
货号 : A873078
分子式 : C7H5FN2O
纯度 : 99%+
分子量 : 152.126
MDL号 : MFCD07781605
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(788.82 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 DAAO inhibitor-1 is a potent D-amino acid oxidase (DAAO) inhibitor. DAAO is a flavoenzyme that degrades D-amino acids through the process of oxidative deamination[1]. DAAO treatment significantly increased RGCs (retinal ganglion cells) survival in the glaucomatous eyes. DAAO treatment induced ERK-1/2 MAP kinase phosphorylation and its upstream regulator, p-MEK increased in the COH (chronic intraocular hypertension) model[2]. Single intravenous injection of the specific and potent DAAO inhibitor Compound SUN reduced the cerebral DAAO enzymic activity and attenuated neuronal infarction and neurobehavioural deficits with optimal improvement apparent immediately after the middle cerebral artery occlusion (MCAO) procedure. The neuroprotective effect was dose dependent, with ED50 values of 3.9-4.5 mg/kg. Intracerebroventricular injection of the DAAO gene silencer siRNA/DAAO significantly reduced cerebral DAAO expression and attenuated MCAO-induced neuronal infarction and behavioural deficits[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

6.57mL

1.31mL

0.66mL

32.87mL

6.57mL

3.29mL

65.73mL

13.15mL

6.57mL
参考文献

[1]Smith SM, Uslaner JM, Hutson PH. The Therapeutic Potential of D-Amino Acid Oxidase (DAAO) Inhibitors. Open Med Chem J. 2010 May 27;4:3-9

[2]Zhang X, Zhang R, Chen J, Wu J. Neuroprotective effects of DAAO are mediated via the ERK1/2 signaling pathway in a glaucomatous animal model. Exp Eye Res. 2020 Jan;190:107892

[3]Liu H, Zhao MJ, Wang ZY, Han QQ, Wu HY, Mao XF, Wang YX. Involvement of d-amino acid oxidase in cerebral ischaemia induced by transient occlusion of the middle cerebral artery in mice. Br J Pharmacol. 2019 Sep;176(17):3336-3349