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T-3775440 HCl

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Chemical Structure| 1422535-52-1 同义名 : T-3775440 hydrochloride
CAS号 : 1422535-52-1
货号 : A871359
分子式 : C18H23ClN4O
纯度 : 99%
分子量 : 346.854
MDL号 : MFCD31692337
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(86.49 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 8 mg/mL(23.06 mM)，配合低频超声，并水浴加热至45℃助溶
动物实验配方：
生物活性
靶点

  • KDM1

    LSD1, IC50:2.1 nM
描述 T-3775440 is an LSD1 inhibitor which inhibits SCLC cell proliferation by disrupting LDS1 interactions with SNAG domain proteins INSM1 and GFI1B.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.88mL

0.58mL

0.29mL

14.42mL

2.88mL

1.44mL

28.83mL

5.77mL

2.88mL
参考文献

[1]Takagi S, Ishikawa Y, et al. LSD1 inhibitor T-3775440 inhibits SCLC cell proliferation by disrupting LDS1 interactions with SNAG domain proteins INSM1 and GFI1B. Cancer Res. 2017 Jun 30. pii: canres.3502.2016.

[2]Ishikawa Y, Gamo K, et al. A Novel LSD1 Inhibitor T-3775440 Disrupts GFI1B-Containing Complex Leading to Transdifferentiation and Impaired Growth of AML Cells. Mol Cancer Ther. 2017 Feb;16(2):273-284.