产品说明书

X-376

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Chemical Structure| 1365267-27-1 同义名 : -
CAS号 : 1365267-27-1
货号 : A868332
分子式 : C25H25Cl2FN6O3
纯度 : 99%
分子量 : 547.409
MDL号 : MFCD25976868
存储条件：

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(191.81 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 X-376 is identified as a highly potent and specific inhibitor of the ALK tyrosine kinase (TKI), boasting an IC50 value of 0.61 nM, making it less effective against MET with an IC50 of 0.69 nM. Its anticancer efficacy is pronounced[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.83mL

0.37mL

0.18mL

9.13mL

1.83mL

0.91mL

18.27mL

3.65mL

1.83mL
参考文献

[1]Lovly CM, et al. Insights into ALK-driven cancers revealed through development of novel ALK tyrosine kinaseinhibitors. Cancer Res. 2011 Jul 15;71(14):4920-31.