MSAB
产品说明书
 |
同义名 : | - |
| CAS号 : | 173436-66-3 | |
| 货号 : | A866132 | |
| 分子式 : | C15H15NO4S | |
| 纯度 : | 98% | |
| 分子量 : | 305.349 | |
| MDL号 : | MFCD00994918 | |
| 存储条件： |
Pure form Inert atmosphere, room temperature In solvent -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
DMSO: 250 mg/mL(818.74 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
|
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Wnt/β-catenin signaling pathway plays crucial roles in multiple stages of development and tissue homeostasis, and its dysregulation can lead to various human diseases. MSAB is a selective inhibitor of Wnt/β-catenin signaling. In HCT116 cells, MSAB resulted in strong inhibition of the TOP-Luc activity in a dose dependent manner. MSAB inhibited proliferation of Wnt-dependent cancer cell lines at concentrations as high as 10 µM. In vivo, MSAB (10 or 20 mg/kg; i.p.; daily for 2 weeks) markedly reduced the size and weight of various types of Wnt-dependent HCT116, HT115, and H23 tumors in xenografted mouse models. Moreover, there was an increase in the level of cleaved caspase 3 in HCT116 and H23 xenograft tumor tissues from mice treated with MSAB, demonstrating that MSAB treatment resulted in apoptotic cell death of tumor xenograft cells leading to subsequent reduction in tumor size[1]. | ||
| 作用机制 | MSAB binds to β-catenin promoting its degradation[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
3.27mL 0.66mL 0.33mL |
16.37mL 3.27mL 1.64mL |
32.75mL 6.55mL 3.27mL |
| 参考文献 |
|---|