Carbenoxolone disodium

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Chemical Structure| 7421-40-1 同义名 : -
CAS号 : 7421-40-1
货号 : A862176
分子式 : C34H48Na2O7
纯度 : 98%
分子量 : 614.72
MDL号 : MFCD03840711
存储条件:

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 16 mg/mL(26.03 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 50 mg/mL(81.34 mM),配合低频超声助溶

动物实验配方:
生物活性
描述 Carbenoxolone disodium, derived from Glycyrrhizic acid, acts as an inhibitor of both human 11β-HSD and bacterial 3α, 20β-HSD enzymes[1]. Carbenoxolone disodium also serves as an uncoupling agent for gap junctions and effectively inhibits the replication of Vaccinia virus[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.63mL

0.33mL

0.16mL

8.13mL

1.63mL

0.81mL

16.27mL

3.25mL

1.63mL

参考文献

[1]W L Duax, et al. Steroid Dehydrogenase Structures, Mechanism of Action, and Disease. Vitam Horm. 2000;58:121-48.

[2]Hossein Hosseinzadeh, et al. Anticonvulsant, Sedative and Muscle Relaxant Effects of Carbenoxolone in Mice. BMC Pharmacol. 2003 Apr 29;3:3.

[3]Ismar R Haga, et al. Carbenoxolone-mediated Cytotoxicity Inhibits Vaccinia Virus Replication in a Human Keratinocyte Cell Line. Sci Rep. 2018 Nov 16;8(1):16956.