DIMBOA

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Chemical Structure| 15893-52-4 同义名 : -
CAS号 : 15893-52-4
货号 : A861298
分子式 : C9H9NO5
纯度 : 99%+
分子量 : 211.172
MDL号 : MFCD01744500
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(236.77 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 DIMBOA [2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one] is a benzoxazinoid (Bx), part of the chemical defense system of graminaceous plants such as maize, wheat, and rye[1]. DIMBOA exhibits a potent free-radical scavenging activity and a weaker iron (III) ions reducing activity. DIMBOA possess growth inhibitory properties against many strains of studied bacteria and fungi, such as Staphylococcus aureus, Escherichia coli as well as against Saccharomyces cerevisiae[2]. The biosynthesis of DIMBOA, a pesticidal secondary metabolite of maize, branches off the tryptophan pathway. The very early and very high level of expression of TSA (tryptophan synthase alpha) corresponds to the timing and level of DIMBOA biosynthesis but is strikingly different from the expression of the maize tryptophan synthase beta (TSB) genes[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.74mL

0.95mL

0.47mL

23.68mL

4.74mL

2.37mL

47.35mL

9.47mL

4.74mL
参考文献

[1]Sasai H, Ishida M, Murakami K, Tadokoro N, Ishihara A, Nishida R, Mori N. Species-specific glucosylation of DIMBOA in larvae of the rice Armyworm. Biosci Biotechnol Biochem. 2009 Jun;73(6):1333-8

[2]Gleńsk M, Gajda B, Franiczek R, Krzyżanowska B, Biskup I, Włodarczyk M. In vitro evaluation of the antioxidant and antimicrobial activity of DIMBOA [2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one]. Nat Prod Res. 2016 Jun;30(11):1305-8

[3]Melanson D, Chilton MD, Masters-Moore D, Chilton WS. A deletion in an indole synthase gene is responsible for the DIMBOA-deficient phenotype of bxbx maize. Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):13345-50