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AG126

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Chemical Structure| 118409-62-4 同义名 : TYRPHOSTINAG126
CAS号 : 118409-62-4
货号 : A860936
分子式 : C10H5N3O3
纯度 : 99%+
分子量 : 215.165
MDL号 : MFCD00236448
存储条件：

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(488 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 AS-8351 is a histone demethylase inhibitor used to induce the reprogramming of fibroblasts into functional cardiomyocytes. Combination of AS8351 with CHIR99021, A83-01, BIX01294, SC1, Y27632 and OAC2 could efficiently induce cardiac reprogramming.
作用机制 AS8351 affects epigenetic modifications by competing with α-ketoglutarate for chelating iron/Fe(II) required by JmjC-KDMs.[1]
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.65mL

0.93mL

0.46mL

23.24mL

4.65mL

2.32mL

46.48mL

9.30mL

4.65mL
参考文献

[1]Cao N, Huang Y, et al. Conversion of human fibroblasts into functional cardiomyocytes by small molecules. Science. 2016 Jun 3;352(6290):1216-20.