Mimosine

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Chemical Structure| 500-44-7 同义名 : L-Mimosine;NSC 69188;Mimosine, Leucenol, Leucaenine;Leucenol
CAS号 : 500-44-7
货号 : A858029
分子式 : C8H10N2O4
纯度 : 98+%
分子量 : 198.176
MDL号 : MFCD00075909
存储条件：

Pure form Keep in dark place,Inert atmosphere,Room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

H2O: 5 mg/mL(25.23 mM)，配合低频超声，水浴加热至45℃，并调节pH至2
动物实验配方：
生物活性
描述 L-Mimosine, an iron chelator and a prolyl 4-hydroxylase inhibitor, blocks many cancer cells at the late G1 phase. L-Mimosine arrested the cell cycle at the G1 phase in PC-3 cells and at the S phase in LNCaP cells, thus attenuating cell proliferation[3]. In addition, L-mimosine is an extremely effective inhibitor of DNA replication in chromosomes of mammalian nuclei. L-mimosine may have an anti-inflammatory effect on chronic inflammation and an inhibitory effect on tumor necrosis factor alpha and interleukin-6 generation in supernatant fluids of minced granulomas[4]. Hypoxia and the hypoxia mimetic agent L-mimosine can stimulate angiopoietin-like 4 production in monolayer cultures of PDLF(periodontal ligament fibroblasts)[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

5.05mL

1.01mL

0.50mL

25.23mL

5.05mL

2.52mL

50.46mL

10.09mL

5.05mL
参考文献

[1]Chung LC, Tsui KH, et al. L-Mimosine blocks cell proliferation via upregulation of B-cell translocation gene 2 and N-myc downstream regulated gene 1 in prostate carcinoma cells. Am J Physiol Cell Physiol. 2012 Feb 15;302(4):C676-85.

[2]Muller HD, Cvikl B, et al. Prolyl hydroxylase inhibitors increase the production of vascular endothelial growth factor in dental pulp-derived cells. J Endod. 2012 Nov;38(11):1498-503.

[3]Chung LC, Tsui KH, Feng TH, Lee SL, Chang PL, Juang HH. L-Mimosine blocks cell proliferation via upregulation of B-cell translocation gene 2 and N-myc downstream regulated gene 1 in prostate carcinoma cells. Am J Physiol Cell Physiol. 2012 Feb 15;302(4):C676-85

[4]Frydas S, Papazahariadou M, Papaioannou N, Hatzistilianou M, Trakatellis M, Merlitti D, Di Gioacchino M, Grilli A, DeLutiis MA, Riccioni G, Conti P, Vlemmas I. Effect of the compound L-mimosine in an in vivo model of chronic granuloma formation induced by potassium permanganate (KMNO4). Int J Immunopathol Pharmacol. 2003 May-Aug;16(2):99-104

[5]Janjić K, Schellner A, Engenhart A, Kernstock K, Schädl B, Moritz A, Agis H. Angiopoietin-like 4 production upon treatment with hypoxia and L-mimosine in periodontal fibroblasts. J Periodontal Res. 2019 Oct;54(5):489-498