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Anabasine

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Chemical Structure| 494-52-0 同义名 : (-)-假木贼碱 ;(S)-Anabasine;(+)-Anabasine;Anabazin
CAS号 : 494-52-0
货号 : A857821
分子式 : C10H14N2
纯度 : 97%
分子量 : 162.232
MDL号 : MFCD00871391
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(647.22 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 ((S)-Anabasine) is a minor alkaloidal component in tobacco (Nicotiana) and functions as a full agonist at nicotinic acetylcholine receptors (nAChRs). It triggers depolarization in TE671 cells, which naturally express human fetal muscle-type nAChRs, with an EC50 value of 0.7 µM[1].[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

6.16mL

1.23mL

0.62mL

30.82mL

6.16mL

3.08mL

61.64mL

12.33mL

6.16mL
参考文献

[1]Levin ED, et al. Effects of tobacco smoke constituents, anabasine and anatabine, on memory and attention in female rats. J Psychopharmacol. 2014 Oct;28(10):915-22.

[2]Benedict T Green, et al. Actions of piperidine alkaloid teratogens at fetal nicotinic acetylcholine receptors. Neurotoxicol Teratol. May-Jun 2010;32(3):383-90.