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Ginsenoside C-K

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Chemical Structure| 39262-14-1 同义名 : 20(S)-人参皂苷 C-K ;Ginsenoside compound K;Ginsenoside K;Ginsenoside CK, Ginsenoside Compound K, Ginsenoside IH901;Ginsenoside IH901
CAS号 : 39262-14-1
货号 : A854334
分子式 : C36H62O8
纯度 : 98+%
分子量 : 622.873
MDL号 : MFCD07772261
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(168.57 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Ginsenoside CK is one of the intestinal bacterial metabolites of ginsenoside prototype saponins. Ginsenoside CK effectively prevented TGF-β-induced EMT, as indicated by the upregulation of E-cadherin and downregulation of vimentin. Furthermore, ginsenoside CK inhibited the metastatic ability of A549 cells in the tail vein lung metastasis model of nude mice[3]. CK (Ginsenoside CK) inhibited viability and proliferation, induced apoptosis, and inhibited the migration and invasion of osteosarcoma cells through the PI3K/mTOR/p70S6K1 signaling pathway[4]. The oral delivery of ginsenoside CK could inhibit the growth of xenograft tumors and block HIF-1α and NF-κB signaling as well as EMT (Epithelial-mesenchymal transformation) marker expression[5]. CK pretreatment promoted cell viability and attenuated ROS accumulation and intracellular mitochondrial damage induced by I/R injury Moreover, CK reduced autophagy by regulating the formation of phagocytic precursors to autophagosomes and also inhibited apoptosis through a mitochondrial-mediated pathway. Additionally the cardioprotective effect of CK against I/R injury was mainly through the activation of the PI3K-Akt signaling pathway[6]. Ginsenoside CK-induced apoptosis of HK-1 cells was mediated by the mitochondrial pathway and could significantly inhibit tumor growth in vivo[7].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.61mL

0.32mL

0.16mL

8.03mL

1.61mL

0.80mL

16.05mL

3.21mL

1.61mL
参考文献

[1]Yang XD, Yang YY, et al. A review of biotransformation and pharmacology of ginsenoside compound K. Fitoterapia. 2015 Jan;100:208-20.

[2]Mathiyalagan R, Subramaniyam S, et al. Ginsenoside compound K-bearing glycol chitosan conjugates: synthesis, physicochemical characterization, and in vitro biological studies. Carbohydr Polym. 2014 Nov 4;112:359-66.

[3]Sun M, Zhuang X, Lv G, Lin Z, Huang X, Zhao J, Lin H, Wang Y. Ginsenoside CK Inhibits TGF-β-Induced Epithelial-Mesenchymal Transition in A549 Cell via SIRT1. Biomed Res Int. 2021 Dec 12;2021:9140191

[4]Chen K, Jiao J, Xue J, Chen T, Hou Y, Jiang Y, Qian L, Wang Y, Ma Z, Liang Z, Sun B, Ren Q. Ginsenoside CK induces apoptosis and suppresses proliferation and invasion of human osteosarcoma cells through the PI3K/mTOR/p70S6K1 pathway. Oncol Rep. 2020 Mar;43(3):886-896

[5]Zhang J, Ma X, Fan D. Ginsenoside CK Inhibits Hypoxia-Induced Epithelial-Mesenchymal Transformation through the HIF-1α/NF-κB Feedback Pathway in Hepatocellular Carcinoma. Foods. 2021 May 26;10(6):1195

[6]Li X, Huang Q, Wang M, Yan X, Song X, Ma R, Jiang R, Zhao D, Sun L. Compound K Inhibits Autophagy-Mediated Apoptosis Through Activation of the PI3K-Akt Signaling Pathway Thus Protecting Against Ischemia/Reperfusion Injury. Cell Physiol Biochem. 2018;47(6):2589-2601

[7]Law CK, Kwok HH, Poon PY, Lau CC, Jiang ZH, Tai WC, Hsiao WW, Mak NK, Yue PY, Wong RN. Ginsenoside compound K induces apoptosis in nasopharyngeal carcinoma cells via activation of apoptosis-inducing factor. Chin Med. 2014 Apr 2;9(1):11