产品说明书
Thalidomide 4-fluoride
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同义名 : | Cereblon ligand 4;E3 ligase Ligand 4;4-Fluoro-thalidomide;TC-E3 5032 |
| CAS号 : | 835616-60-9 | |
| 货号 : | A850967 | |
| 分子式 : | C13H9FN2O4 | |
| 纯度 : | 98% | |
| 分子量 : | 276.22 | |
| MDL号 : | MFCD11840666 | |
| 存储条件： |
粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 300 mg/mL(1086.09 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Thalidomide 4-fluoride, known as Cereblon ligand 4, is a derivative of Thalidomide designed to engage the CRBN protein. This compound is instrumental in the construction of PROTAC IRAK4 degrader-1, wherein it is linked to the IRAK4 protein ligand, highlighting its utility in targeted protein degradation[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.62mL 0.72mL 0.36mL |
18.10mL 3.62mL 1.81mL |
36.20mL 7.24mL 3.62mL |
| 参考文献 |
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[1]Nello Mainolfi, et al. Irak degraders and uses thereof. US20190192668A1. |