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EGFR/ErbB-2/ErbB-4 inhibitor-2

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Chemical Structure| 179248-61-4 同义名 : EGFR/ErbB2 Inhibitor;ErbB2 inhibitor;4557W
CAS号 : 179248-61-4
货号 : A850202
分子式 : C23H21N3O3
纯度 : 99%+
分子量 : 387.431
MDL号 : MFCD08758375
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 35 mg/mL(90.34 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • HER2/ErbB2

    ErbB2, IC50:0.08 μM

  • ErbB4

    ErbB4, IC50:1.91 μM
描述 EGFR/ErbB-2/ErbB-4 inhibitor-2 is an epidermal growth factor receptor and ErbB inhibitor with IC50 values of 0.017 μM, 0.08 μM, and 1.91 μM, respectively. It also inhibits c-Src, VEGFR2, and c-Fms, with IC50s of 0.30, 2.2, and 14.0 μM, respectively[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.58mL

0.52mL

0.26mL

12.91mL

2.58mL

1.29mL

25.81mL

5.16mL

2.58mL
参考文献

[1]Perry S Brignola, et al. Comparison of the biochemical and kinetic properties of the type 1 receptor tyrosine kinase intracellular domains. Demonstration of differential sensitivity to kinase inhibitors. J Biol Chem. 2002 Jan 11;277(2):1576-85.