产品说明书

Oseltamivir acid

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Chemical Structure| 187227-45-8 同义名 : Ro 64-0802;Oseltamivir carboxylate;GS 4071
CAS号 : 187227-45-8
货号 : A850094
分子式 : C14H24N2O4
纯度 : 98%
分子量 : 284.351
MDL号 : MFCD00953940
存储条件：

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 200 mg/mL(703.36 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(351.68 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Oseltamivir acid is an active metabolite of oseltamivir, which is a potent and selective inhibitor of influenza A and B virus neuraminidases.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.52mL

0.70mL

0.35mL

17.58mL

3.52mL

1.76mL

35.17mL

7.03mL

3.52mL
参考文献

[1]Ferraris O, Kessler N, et al. Sensitivity of influenza viruses to zanamivir and oseltamivir: a study performed on viruses circulating in France prior to the introduction of neuraminidase inhibitors in clinical practice. Antiviral Res. 2005 Oct;68(1):43-8.

[2]Gubareva LV, Webster RG, et al. Comparison of the activities of zanamivir, oseltamivir, and RWJ-270201 against clinical isolates of influenza virus and neuraminidase inhibitor-resistant variants. Antimicrob Agents Chemother. 2001 Dec;45(12):3403-8.