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Dimethyl malonate

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Chemical Structure| 108-59-8 同义名 : -
CAS号 : 108-59-8
货号 : A847141
分子式 : C5H8O4
纯度 : 99%
分子量 : 132.115
MDL号 : MFCD00008460
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(794.76 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(756.92 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Dimethylmalonate is a competitive SDH (succinate dehydrogenase) inhibitor. It led to an increase in succinate in the cytosol, presumably by impairing the oxidation of succinate to fumarate, and also boosted LPS-induced succinate accumulation. Limiting succinate oxidation by dimethylmalonate induced an anti-inflammatory response at 10mM in BMDMs. Dimethylmalonate, at dose of 160 mg/kg, i.p., also showed anti-inflammatory effect on LPS-induced sepsis mice model. It decreased serum levels of IL-1β and boosted IL-10, but had no significant effect on TNF-α, as well as reduced IL-1β and PHD3 expression in the spleen[1].
作用机制 Dimethylmalonate is a competitive SDH inhibitor.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

7.57mL

1.51mL

0.76mL

37.85mL

7.57mL

3.78mL

75.69mL

15.14mL

7.57mL
参考文献

[1]Repurposing mitochondria from ATP production to ROS generation drives a pro-inflammatory phenotype in macrophages that depends on succinate oxidation by complex II