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Valproic acid sodium

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Chemical Structure| 1069-66-5 同义名 : 2-丙戊酸钠 ;Sodium Valproate sodium;Valproic Acid (sodium salt);Valproic Acid, Convulex, Depakote, Epilim, Stavzor, Vilapro;VPA;Valproate;2-Propylvaleric Acid
CAS号 : 1069-66-5
货号 : A841103
分子式 : C8H15NaO2
纯度 : 97%
分子量 : 166.193
MDL号 : MFCD00078604
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

H2O: 120 mg/mL(722.05 mM)，配合低频超声助溶
动物实验配方：
生物活性
靶点

  • HDAC

  • Autophagy

  • GABA receptor
描述 Valproic acid sodium is a histone deacetylase (HDAC) inhibitor (IC50=10 μM in Hela cell, 24h) has an anticancer effect.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

6.02mL

1.20mL

0.60mL

30.09mL

6.02mL

3.01mL

60.17mL

12.03mL

6.02mL
参考文献

[1]Phiel CJ, Zhang F, et al. Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J Biol Chem. 2001 Sep 28;276(39):36734-41.

[2]Gottlicher M, Minucci S, et al. Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells. EMBO J. 2001 Dec 17;20(24):6969-78.