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Praeruptorin A

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Chemical Structure| 73069-27-9 同义名 : 白花前胡甲素 ;(+)-Praeruptorin A
CAS号 : 73069-27-9
货号 : A839991
分子式 : C21H22O7
纯度 : 98%
分子量 : 386.395
MDL号 : MFCD02752489
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 35 mg/mL(90.58 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • Calcium Channel
描述 (+)-Praeruptorin A is a natural product isolated and purified from the roots of Peucedanum praeruptorum Dunn., which exerted distinct relaxant effects on isolated rat aorta rings, which might be mainly attributed to nitric oxide synthesis catalyzed by endothelial nitric oxide synthase.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.59mL

0.52mL

0.26mL

12.94mL

2.59mL

1.29mL

25.88mL

5.18mL

2.59mL
参考文献

[1]Liu X, Chen DW, et al. The Inhibition of UDP-Glucuronosyltransferase (UGT) Isoforms by Praeruptorin A and B. Phytother Res. 2016 Nov;30(11):1872-1878.

[2]Yeon JT, Choi SW, et al. Praeruptorin A inhibits in vitro migration of preosteoclasts and in vivo bone erosion, possibly due to its potential to target calmodulin. J Nat Prod. 2015 Apr 24;78(4):776-82.