Cl-amidine HCl
产品说明书
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同义名 : | Cl-Amidine (hydrochloride);Cl-amidine hydrochloride |
| CAS号 : | 1373232-26-8 | |
| 货号 : | A835276 | |
| 分子式 : | C14H20Cl2N4O2 | |
| 纯度 : | 98% | |
| 分子量 : | 347.24 | |
| MDL号 : | MFCD22201084 | |
| 存储条件： |
Pure form Inert atmosphere,2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 50 mg/mL(143.99 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 50 mg/mL(143.99 mM)，配合低频超声助溶 |
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| 动物实验配方： |
| 生物活性 | |||
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| 描述 | Cl-amidine is an irreversible pan-peptidylarginine deiminase (PAD) inhibitor with IC50 values of with IC50 values of 5.9 ± 0.3 μM, 0.8 ± 0.3 μM, 6.2 ± 1.0 μM for PAD4, PAD1 and PAD3, respectively[1]. It is cytotoxic to HL-60, MCF-7, and HT-29 cancer cells (IC50s = 0.25, 0.05, and 1 μM, respectively)[2]. Cl-amidine (0, 5, 10, 15, 20, 25, 50 μg/mL) induces apoptosis in TK6 lymphoblastoid cells and HT29 colon cancer cells in a dose-dependent manner. Cl-amidine (75 mg/kg) can significantly increase the levels of p21 and p53 in colonic epithelial inflammatory cells of colitis C57BL/6 mice, and induce apoptosis[3]. | ||
| 实验方案 | |||
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| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.88mL 0.58mL 0.29mL |
14.40mL 2.88mL 1.44mL |
28.80mL 5.76mL 2.88mL |
| 参考文献 |
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