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ML266

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Chemical Structure| 1462267-08-8 同义名 : -
CAS号 : 1462267-08-8
货号 : A835034
分子式 : C24H22BrN3O4
纯度 : 98%
分子量 : 496.353
MDL号 : MFCD29477343
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(241.76 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 ML266 acts as a chaperone for glucocerebrosidase (GCase) with an IC50 of 2.5 µM. It binds to GCase, facilitating the transport of the mutant protein to the lysosome and restoring GCase activity. ML266 does not inhibit the enzymatic function of GCase. This makes ML266 a candidate for research into Gaucher disease[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.01mL

0.40mL

0.20mL

10.07mL

2.01mL

1.01mL

20.15mL

4.03mL

2.01mL
参考文献

[1]Rogers S, et al. Discovery, SAR, and Biological Evaluation of Non-inhibitory Chaperones of Glucocerebrosidase. 2012 Mar 27 [updated 2013 Mar 7].