产品说明书
3-O-trans-p-Coumaroyltormentic acid
 |
同义名 : | - |
| CAS号 : | 121064-78-6 | |
| 货号 : | A834725 | |
| 分子式 : | C39H54O7 | |
| 纯度 : | 98+% | |
| 分子量 : | 634.842 | |
| MDL号 : | MFCD28100311 | |
| 存储条件： |
粉末 液体 -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | 3-O-trans-p-Coumaroyltormentic acid, a natural product isolated and purified from the leaves of Eriobotrya japonica calli, induces apoptotic cell death in human leukemia (HL60) via mainly mitochondrial pathway by, at least in part, Topo I inhibition, and may be promising lead compound for developing an effective drug for treatment of leukemia. 3-O-trans-p-coumaroyltormentic acid shows cytotoxicity against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-15) in vitro, the IC50 values of 13.72, 14.29,14.61, 14.04 uM, respectively, and is weakly selective for vancomycin-resistant Enterococcus (VRE) compared with eukaryotic cells, with an MIC of 59.4mg/mL and a 50% inhibitory concentration (IC50) of 72.0mg/mL for monkey kidney epithelial (MA104) cells. It also shows an inhibitory effect comparable to (-)-epigallocatechin gallate (EGCG) of green tea on the activation of Epstein-Barr virus early antigen (EBV-EA) induced by 12-O-tetradeca--noylphorbol-13-acetate (TPA). | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
1.58mL 0.32mL 0.16mL |
7.88mL 1.58mL 0.79mL |
15.75mL 3.15mL 1.58mL |
| 参考文献 |
|---|