产品说明书
Virodhamine
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同义名 : | - |
| CAS号 : | 287937-12-6 | |
| 货号 : | A831315 | |
| 分子式 : | C22H37NO2 | |
| 纯度 : | 95% | |
| 分子量 : | 347.535 | |
| MDL号 : | MFCD06654562 | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(302.13 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Virodhamine is an endogenous cannabinoid that regulates neurotransmission through activation of cannabinoid (CB) receptors. Virodhamine is an antagonist of CB1 receptors and an agonist of CB2 receptors. Virodhamine induces megakaryocyte differentiation by triggering MAPK signalling and generating ROS. Virodhamine can be Virodhamine has been used in the study of various neurological diseases such as Alzheimer's disease and Parkinson's disease[1][2].At a concentration of 50 nM, treating for 72 hours, Virodhamine increases adhesion, membrane expansion and nucleus size. At concentrations in the range of 10-40 μM for 72 h, Virodhamine increases the expression levels of CD61 and TRPV1. Virodhamine inhibits cell proliferation in megakaryocytes and significantly increases the proportion of hyperploid cells[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.88mL 0.58mL 0.29mL |
14.39mL 2.88mL 1.44mL |
28.77mL 5.75mL 2.88mL |
| 参考文献 |
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