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UDP-glucuronic acid trisodium

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Chemical Structure| 63700-19-6 同义名 : 尿苷二磷酸葡糖醛酸 ;Udpgatrisodiumsalt
CAS号 : 63700-19-6
货号 : A828611
分子式 : C15H19N2Na3O18P2
纯度 : 99%+
分子量 : 646.231
MDL号 : MFCD00037687
存储条件：

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 18 mg/mL(27.85 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 120 mg/mL(185.69 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 UDP-glucuronic acid trisodium is a critical precursor for essential glycoconjugates across biological kingdoms, ranging from mammalian glycosaminoglycans and plant cell wall polysaccharides to bacterial capsule glycoglycerolipids[1]. UDP-glucuronic acid (UDP-GlcA) is also common substrate for C4-epimerases and decarboxylases releasing UDP-galacturonic acid (UDP-GalA) and UDP-pentose products, respectively[2]. UDP-glucuronic acid pyrophosphorylase from zebrafish has homology to bacterial nucleotidyltransferases and requires UTP as nucleosid diphosphate donor[3]. Moreover, depletion of the hyaluronic acid precursor UDP-glucuronic acid is sufficient to inhibit several mesenchymal-like properties including cellular invasion and colony formation in vitro, as well as tumor growth and metastasis in vivo. And depletion of UDP-glucuronic acid altered the expression of PPAR-gamma target genes and increased PPAR-gamma DNA-binding activity[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.55mL

0.31mL

0.15mL

7.74mL

1.55mL

0.77mL

15.47mL

3.09mL

1.55mL
参考文献

[1]Li LX, Rautengarten C, Heazlewood JL, Doering TL. UDP-Glucuronic Acid Transport Is Required for Virulence of Cryptococcus neoformans. mBio. 2018 Jan 30;9(1):e02319-17

[2]Borg AJE, Dennig A, Weber H, Nidetzky B. Mechanistic characterization of UDP-glucuronic acid 4-epimerase. FEBS J. 2021 Feb;288(4):1163-1178

[3]Gangl R, Behmüller R, Tenhaken R. Molecular cloning of a novel glucuronokinase/putative pyrophosphorylase from zebrafish acting in an UDP-glucuronic acid salvage pathway. PLoS One. 2014 Feb 28;9(2):e89690

[4]Arnold JM, Gu F, Ambati CR, Rasaily U, Ramirez-Pena E, Joseph R, Manikkam M, San Martin R, Charles C, Pan Y, Chatterjee SS, Den Hollander P, Zhang W, Nagi C, Sikora AG, Rowley D, Putluri N, Zhang XH, Karanam B, Mani SA, Sreekumar A. UDP-glucose 6-dehydrogenase regulates hyaluronic acid production and promotes breast cancer progression. Oncogene. 2020 Apr;39(15):3089-3101