RSM-932A

产品说明书

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Chemical Structure| 850807-63-5 同义名 : TCD-717
CAS号 : 850807-63-5
货号 : A823730
分子式 : C46H38Br2Cl2N4
纯度 : 99%+
分子量 : 877.535
MDL号 : MFCD29058562
存储条件：

Pure form Inert atmosphere,Room Temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 16 mg/mL(18.23 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 RSM-932A is an anticancer drug targeting the human choline kinase alpha, an enzyme involved in increased lipid metabolism of cancer cells.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.14mL

0.23mL

0.11mL

5.70mL

1.14mL

0.57mL

11.40mL

2.28mL

1.14mL
参考文献

[1]Lacal JC, Campos JM. Preclinical characterization of RSM-932A, a novel anticancer drug targeting the human choline kinase alpha, an enzyme involved in increased lipid metabolism of cancer cells. Mol Cancer Ther. 2015 Jan;14(1):31-9.

[2]Zimmerman T, Moneriz C, et al. Antiplasmodial activity and mechanism of action of RSM-932A, a promising synergistic inhibitor of Plasmodium falciparum choline kinase. Antimicrob Agents Chemother. 2013 Dec;57(12):5878-88.