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Zatebradine HCl

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Chemical Structure| 91940-87-3 同义名 : UL-FS-49;UL-FS-49CL;Zatebradine (hydrochloride);Zatebradine hydrochloride
CAS号 : 91940-87-3
货号 : A819159
分子式 : C26H37ClN2O5
纯度 : 98+%
分子量 : 493.035
MDL号 : MFCD06798356
存储条件：

粉末

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(212.97 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(202.83 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Zatebradine hydrochloride is a potent HCN channels antagonist, which decreased the heartbeat in a reversible manner with 92% inhibition of the hHCN1-mediated current at 10 μM.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.03mL

0.41mL

0.20mL

10.14mL

2.03mL

1.01mL

20.28mL

4.06mL

2.03mL
参考文献

[1]Matt L, Michalakis S, et al. HCN2 channels in local inhibitory interneurons constrain LTP in the hippocampal direct perforant path. Cell Mol Life Sci. 2011 Jan;68(1):125-37.

[2]Gill CH, Randall A, et al. Characterization of the human HCN1 channel and its inhibition by capsazepine. Br J Pharmacol. 2004 Oct;143(3):411-21.