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DY268

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Chemical Structure| 1609564-75-1 同义名 : -
CAS号 : 1609564-75-1
货号 : A818184
分子式 : C30H32N4O5S
纯度 : 98%
分子量 : 560.664
MDL号 : MFCD30182341
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(89.18 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 DY268 is an FXR antagonist with an IC50 value of 7.5 nM. It inhibits the transcriptional activation of FXR in cell-based assays with an IC50 value of 468 nM. DY268 can be used to study drug-induced liver injury (DILI)[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.78mL

0.36mL

0.18mL

8.92mL

1.78mL

0.89mL

17.84mL

3.57mL

1.78mL
参考文献

[1]Yu DD, Lin W, Forman BM, Chen T. Identification of trisubstituted-pyrazol carboxamide analogs as novel and potent antagonists of farnesoid X receptor. Bioorg Med Chem. 2014 Jun 1;22(11):2919-38.

[2]Kyounghwa Jung, et al. Farnesoid X Receptor Activation Impairs Liver Progenitor Cell-Mediated Liver Regeneration via the PTEN-PI3K-AKT-mTOR Axis in Zebrafish. Hepatology. 2021 Jul;74(1):397-410.