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Benzoic acid

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Chemical Structure| 65-85-0 同义名 : -
CAS号 : 65-85-0
货号 : A806843
分子式 : C7H6O2
纯度 : 99%
分子量 : 122.121
MDL号 : MFCD00002398
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(859.8 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 7 mg/mL(57.32 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Benzoic acid is an aromatic carboxylic acid naturally present in plant and animal tissues, which can also be produced by microorganisms. Benzoic acid and a wide range of derivatives and related benzenic compounds, such as salts, alkyl esters, parabens, benzyl alcohol, benzaldehyde, and benzoyl peroxide, are commonly used as antibacterial and antifungal preservatives and as flavoring agents in food, cosmetic, hygiene, and pharmaceutical products[3]. Moreover, using appropriate benzoic acid levels might improve gut functions via regulating enzyme activity, redox status, immunity, and microbiota, but excess administration would lead to the damage of gut health through redox status[4]. Moreover, chemical necrectomy using 40% benzoic acid is a selective method comparable with other types of sharp necrectomy. Toxicity of absorbed benzoic acid is clinically negligible. Furthermore, benzoic acids antimycotic and antibacterial properties prevent the development of wound infection[5].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03268577 - Completed - United States, Maryland ... 展开 >> NCI Division of Cancer Control and Population Sciences Bethesda, Maryland, United States, 20892 收起 <<
NCT02744469 - Active, not recruiting December 12, 2019 Belgium ... 展开 >> Institute of Tropical Medicine Antwerp, Belgium Benin Centre de Diagnostic et de Traitement de la Tuberculose de Djougou Djougou, Atacora/Donga, Benin Centre de Diagnostic et de Traitement de la Tuberculose de Matéri Matéri, Atacora/Donga, Benin Centre de Diagnostic et de Traitement de la Tuberculose de Natitingou Natitingou, Atacora/Donga, Benin Centre de Diagnostic et de Traitement de la Tuberculose de Tanguiéta Tanguiéta, Atacora/Donga, Benin Centre de Diagnostic et de Traitement de la tuberculose d'Abomey-Calavi Abomey-Calavi, Atlantique/Littoral, Benin Centre de Diagnostic et de Traitement de la Tuberculose d'Allada Allada, Atlantique/Littoral, Benin Centre National Hospitalier Universitaire de Pneumo-Phtisiologie de Cotonou Cotonou, Atlantique/Littoral, Benin, 01BP321 Centre de Diagnostic et de Traitement de la Tuberculose de Ouidah Ouidah, Atlantique/Littoral, Benin Centre de Diagnostic et de Traitement de la Tuberculose de Bembèrèkè HE Bembèrèkè, Borgou/Alibori, Benin Centre de Diagnostic et de Traitement de la Tuberculose de Kandi Kandi, Borgou/Alibori, Benin Centre de Diagnostic et de Traitement de la Tuberculose de Nikki Hopital Sounou-Séro Nikki, Borgou/Alibori, Benin Centre de Diagnostic et de Traitement de la Tuberculose de Parakou CSCom Parakou, Borgou/Alibori, Benin Laboratoire de Référence des Mycobactéries Cotonou, Littoral, Benin, 01BP321 Centre de Diagnostic et de Traitement de la Tuberculose d'Aplahoué Aplahoué, Mono/Couffo, Benin Centre de Diagnostic et de Traitement de la Tuberculose de Bopa Bopa, Mono/Couffo, Benin Centre de Diagnostic et de Traitement de la Tuberculose de Comè Comè, Mono/Couffo, Benin Centre de Diagnostic et de Traitement de la Tuberculose de Houéyogbé Houéyogbé, Mono/Couffo, Benin Centre de Diagnostic et de Traitement de la Tuberculose de Avrankou Avrankou, Oueme/Plateau, Benin Centre de Diagnostic et de Traitement de la Tuberculose de Pobè Pobe, Oueme/Plateau, Benin Centre de Pneumo-Phtisiologie d'Akron Porto-Novo, Oueme/Plateau, Benin Centre de Diagnostic et de Traitement de la Tuberculose de Sakété Sakété, Oueme/Plateau, Benin Centre de Diagnostic et de Traitement de la Tuberculose d'Abomey Abomey, Zou/Collines, Benin Centre de Diagnostic et de Traitement de la Tuberculose de Bohicon Bohicon, Zou/Collines, Benin Centre de Diagnostic et de Traitement de la Tuberculose de Dassa-Zoumè Dassa-Zoumè, Zou/Collines, Benin Centre de Diagnostic et de Traitement de la Tuberculose de Zagnanado Zagnanado, Zou/Collines, Benin 收起 <<
NCT01179945 Overweight Not Applicable Completed - United States, Massachusetts ... 展开 >> Massachusetts General Hospital Boston, Massachusetts, United States, 02101 Children's Hospital Boston, Massachusetts, United States, 02115 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

8.19mL

1.64mL

0.82mL

40.94mL

8.19mL

4.09mL

81.89mL

16.38mL

8.19mL
参考文献

[1]Tsuji A, Takanaga H, et al. Transcellular transport of benzoic acid across Caco-2 cells by a pH-dependent and carrier-mediated transport mechanism. Pharm Res. 1994 Jan;11(1):30-7.

[2]Tremblay GC, Qureshi IA. The biochemistry and toxicology of benzoic acid metabolism and its relationship to the elimination of waste nitrogen. Pharmacol Ther. 1993 Oct;60(1):63-90.

[3]Del Olmo A, Calzada J, Nuñez M. Benzoic acid and its derivatives as naturally occurring compounds in foods and as additives: Uses, exposure, and controversy. Crit Rev Food Sci Nutr. 2017;57(14):3084-3103

[4]Mao X, Yang Q, Chen D, Yu B, He J. Benzoic Acid Used as Food and Feed Additives Can Regulate Gut Functions. Biomed Res Int. 2019;2019:5721585. Published 2019 Feb 26

[5]Jelínková Z, Kaloudová Y, Řihová H, Suchánek I, Brychta P. OUR EXPERIENCE WITH THE USE OF 40% BENZOIC ACID FOR NECRECTOMY IN DEEP BURNS. NAŠE ZKUŠENOSTI S VYUŽITÍM 40% KYSELINY BENZOOVÉ PŘI NEKREKTOMII U HLUBOKÝCH POPÁLENIN. Acta Chir Plast. 2017;59(1):5-10