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AS2444697

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Chemical Structure| 1287665-60-4 同义名 : AS-2444697 (hydrochloride)
CAS号 : 1287665-60-4
货号 : A805441
分子式 : C19H21ClN6O4
纯度 : 98%
分子量 : 432.861
MDL号 : MFCD30182294
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 12 mg/mL(27.72 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 AS2444697, an orally active IRAK-4 inhibitor, shows an IC50 of 21 nM, effectively inhibiting both human and rat IRAK-4 activity[1]. AS2444697 also exerts renoprotective effects through its anti-inflammatory actions[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.31mL

0.46mL

0.23mL

11.55mL

2.31mL

1.16mL

23.10mL

4.62mL

2.31mL
参考文献

[1]JohnHynesJr, et al. Chapter Nine - Advances in the Discovery of Small-Molecule IRAK4 Inhibitors. Annu Rep Med Chem. 2014 (49):117-133.

[2]Mitsuhiro Kondo, et al. Renoprotective effects of novel interleukin-1 receptor-associated kinase 4 inhibitor AS2444697 through anti-inflammatory action in 5/6 nephrectomized rats. Naunyn Schmiedebergs Arch Pharmacol. 2014 Oct;387(10):909-19.