产品说明书
Histamine
 |
同义名 : | Ergamine;NSC 33792 |
| CAS号 : | 51-45-6 | |
| 货号 : | A804010 | |
| 分子式 : | C5H9N3 | |
| 纯度 : | 97% | |
| 分子量 : | 111.145 | |
| MDL号 : | - | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
H2O: 30 mg/mL(269.92 mM) |
|
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Histamine is an organic nitrogenous compound involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter. Histamine acts via H1 and H2 receptors to produce vasodilation and increased vascular permeability; elevated levels of histamine are found in inflamed tissue[3]. Bilateral EP (experimental periodontitis) was induced for 2 weeks and histamine treatment (0.1 mg/kg subcutaneously) was started 5 days before the end of the experimental period in male rats. Histamine treatment partially reversed the methacholine-induced salivation reduction produced by EP while preventing SMG (submandibular gland) histological damage. Furthermore, histamine completely prevented enhanced EP-induced apoptosis. Histamine is able to reduce periodontitis-induced damage to SMG and bone structure[4]. Histamines play an important role as a neurotransmitter in the central nervous system and participate in several physiological functions, such as the regulation of body temperature, food intake, circadian rhythm and analgesia. Histamines facilitate memory performance in mice[5]. In HL-60 cells, histamine and 2-methylhistamine increased cytosolic Ca2+ concentration ([Ca2+]i) in a clemastine-sensitive manner. Histamine and 2-methylhistamine act as H1-receptor agonists in HL-60 cells[6]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
9.00mL 1.80mL 0.90mL |
44.99mL 9.00mL 4.50mL |
89.97mL 17.99mL 9.00mL |
