NVR 3-778

产品说明书

Print
Chemical Structure| 1445790-55-5 同义名 : -
CAS号 : 1445790-55-5
货号 : A803243
分子式 : C18H16F4N2O4S
纯度 : 99%
分子量 : 432.389
MDL号 : N/A
存储条件:

Pure form Sealed in dry,Store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 250 mg/mL(578.18 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.31mL

0.46mL

0.23mL

11.56mL

2.31mL

1.16mL

23.13mL

4.63mL

2.31mL

参考文献

[1]Yuen MF, Gane EJ, Kim DJ, Weilert F, Yuen Chan HL, Lalezari J, Hwang SG, Nguyen T, Flores O, Hartman G, Liaw S, Lenz O, Kakuda TN, Talloen W, Schwabe C, Klumpp K, Brown N. Antiviral Activity, Safety, and Pharmacokinetics of Capsid Assembly Modulator NVR 3-778 in Patients with Chronic HBV Infection. Gastroenterology. 2019 Apr;156(5):1392-1403.e7. doi: 10.1053/j.gastro.2018.12.023. Epub 2019 Jan 6. PMID: 30625297.

[2]Lv K, Li W, Wu S, Geng Y, Wang A, Yang L, Huang M, Chowdhury K, Li Y, Liu M. Amino acid prodrugs of NVR3-778: Design, synthesis and anti-HBV activity. Bioorg Med Chem Lett. 2020 May 1;30(9):127103. doi: 10.1016/j.bmcl.2020.127103. Epub 2020 Mar 9. PMID: 32173194.