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NMS-859

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Chemical Structure| 1449236-96-7 同义名 : -
CAS号 : 1449236-96-7
货号 : A799531
分子式 : C15H12ClN3O3S
纯度 : 99%+
分子量 : 349.792
MDL号 : MFCD05030984
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(142.94 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 NMS-859 is a potent VCP inhibitor, with IC50s of 0.37 and 0.36 μM against wild-type VCP in the presence of 60 μM and 1 mM ATP in cellular contexts, respectively. It exhibits minimal inhibitory action against VCPC522T mutation. NMS-859 also inhibits cell proliferation, with IC50 values of 3.5 μM for HCT116 cells and 3.0 μM for HeLa cells[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.86mL

0.57mL

0.29mL

14.29mL

2.86mL

1.43mL

28.59mL

5.72mL

2.86mL
参考文献

[1]Magnaghi P, et al. Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death. Nat Chem Biol. 2013 Sep;9(9):548-56.