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Apigenin-7-O-β-D-glucopyranoside

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Chemical Structure| 578-74-5 同义名 : 芹甙元-7-葡萄糖苷 ;Apigetrin;Cosmosiin;NSC 407303;Apigenin-7-O-β-D-glucoside;7-O-β-D-Glucopyranosylapigenin;Cosmosin;Thalictiin;Cosmosioside;Cosmetin;Apigenin 7-glucoside
CAS号 : 578-74-5
货号 : A798095
分子式 : C21H20O10
纯度 : 99%+
分子量 : 432.377
MDL号 : MFCD00016787
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(242.84 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Apigenin-7-glucoside (Apigenin-7-O-β-D-glucopyranoside) exhibits significant anti-proliferative and antioxidant activity and scavenges reactive oxygen species (ROS). Apigenin-7-glucoside, genkwanin and naringenin exhibited significant anti-proliferative activity against B16F10 melanoma cells after 24 and 48 h of incubation. Furthermore, apigenin-7-glucoside, genkwanin and naringenin provoked an increase of subG0/G1, S and G2/M phase cell proportion with a significant decrease of cell proportion in G0/G1 phases. Moreover, apigenin-7-glucoside and naringenin revealed an ability to enhance melanogenesis synthesis and tyrosinase activity of B16F10 melanoma cells[3]. Apigenin 7-glucoside specifically induces the differentiation of CD34+ cells towards the erythroid lineage and inhibited the myeloid differentiation. Apigenin 7-glucoside has strong antioxidant activity against reactive oxygen species (ROS) in vitro in a concentration-dependent manner[4]. In aaddition, with regard to the antiplasmodial activity, apigenin 7-glucoside was the most effective compound[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.31mL

0.46mL

0.23mL

11.56mL

2.31mL

1.16mL

23.13mL

4.63mL

2.31mL
参考文献

[1]Nasr Bouzaiene N, Chaabane F, et al. Effect of apigenin-7-glucoside, genkwanin and naringenin on tyrosinase activity and melanin synthesis in B16F10 melanoma cells. Life Sci. 2016 Jan 1;144:80-5.

[2]Samet I, Villareal MO, et al. Olive leaf components apigenin 7-glucoside and luteolin 7-glucoside direct human hematopoietic stem cell differentiation towards erythroid lineage. Differentiation. 2015 Jun;89(5):146-55.

[3]Nasr Bouzaiene N, Chaabane F, Sassi A, Chekir-Ghedira L, Ghedira K. Effect of apigenin-7-glucoside, genkwanin and naringenin on tyrosinase activity and melanin synthesis in B16F10 melanoma cells. Life Sci. 2016 Jan 1;144:80-5

[4]Samet I, Villareal MO, Motojima H, Han J, Sayadi S, Isoda H. Olive leaf components apigenin 7-glucoside and luteolin 7-glucoside direct human hematopoietic stem cell differentiation towards erythroid lineage. Differentiation. 2015 Jun;89(5):146-55

[5]Vitalini S, Beretta G, Iriti M, Orsenigo S, Basilico N, Dall'Acqua S, Iorizzi M, Fico G. Phenolic compounds from Achillea millefolium L. and their bioactivity. Acta Biochim Pol. 2011;58(2):203-9. Epub 2011 Apr 19