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描述 | Quinapril Hydrochloride is the hydrochloride salt form of quinapril, a prodrug and non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Quinapril inhibits the contractile and pressor effects of angiotensin I in rabbit aorta and in rats, respectively, and lowers blood pressure in both high- and normal-renin rodent and diuretic-treated dog models of hypertension. Long-term toxicology studies show that quinapril is not teratogenic, carcinogenic, or mutagenic[3]. Quinapril produced minimal adverse effects on renal function in both patients with normal renal function and in those with pre-existing renal impairment[4]. Quinaprilat has a strong binding capacity to tissue ACE allowing for once-daily dosing. The recommended starting dose for quinapril is 20 mg/d. Quinapril's antihypertensive efficacy is equal to that of captopril and enalapril[5]. Hemodynamic studies in dogs indicate that quinapril decreases total peripheral and renal vascular resistance. Quinapril is well tolerated in a variety of pharmacologic safety screens and its toxicity profile is similar to that of other ACE inhibitors[6]. |
临床研究 | |||||
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NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT02817360 | Heart Diseases ... 展开 >> Diabetes Mellitus, Type 2 收起 << | Phase 4 | Recruiting | February 2021 | Austria ... 展开 >> Internistische Ordination Recruiting Mödling, Niederösterreich, Austria, 2340 Contact: Christian Feinböck, MD +43 2236 869 142 office@dr-feinboeck.at Contact: Christiane Feinböck +43 2236 869 142 office@dr-feinboeck.at Sub-Investigator: Egbert Seyfried, MD Principal Investigator: Christian Feinböck, MD Klinischen Abteilung für Endokrinologie und Diabetologie MU Graz Recruiting Graz, Steiermark, Austria, 8036 Contact: Harald Sourij +43-316-385-80363 ha.sourij@medunigraz.at Contact: Michael Zink +43-680-128-5120 m.zink@medunigraz.at Sub-Investigator: Julia Mader, MD Prof Sub-Investigator: Eva Novak, MD Sub-Investigator: Caren Sourij, MD Konventhospital der Barmherzigen Brüder Abteilung für Innere Medizin Recruiting Linz, Upper Austria, Austria, 4021 Contact: Martin Clodi, Prof.Dr. martin.clodi@bblinz.at Principal Investigator: Martin Clodi, Prof.Dr. Sub-Investigator: Michael Resl, Dr. Krankenanstalt Rudolfstiftung, 1. Medizinische Abteilung Recruiting Vienna, Austria, 1030 Contact: Bernhard Ludvik, Prof.Dr. +43 1 711 65 ext 2107 bernhard.ludvik@wienkav.at Principal Investigator: Bernhard Ludvik, Prof.Dr. Sub-Investigator: Eva-Christina Krzizek, Dr. Sub-Investigator: Johanna Brix, Dr. Sub-Investigator: Astrid Feder, Dr. Sub-Investigator: Florian Hoellerl, Dr. Medical University of Vienna Univ.Clinic for Internal Medicine II Department of Cardiology Recruiting Vienna, Austria, 1090 Contact: Martin Huelsmann, Doz.Dr. +43 1 40400 ext 46140 martin.huelsmann@meduniwien.ac.at Principal Investigator: Martin Huelsmann, Doz.Dr. Sub-Investigator: Raphael Wurm, Dr. Univ. Klinik für Innere Medizin III Med. Uni Wien Recruiting Vienna, Austria, 1090 Contact: Anton Luger, Prof.Dr. 00 43 1 40400 ext 43100 anton.luger@meduniwien.ac.at Principal Investigator: Anton Luger, Prof.Dr. Sub-Investigator: Michael Krebs, Prof.Dr. Universitätsklinik für Augenheilkunde und Optometrie Medizinische Universität Wien Recruiting Vienna, Austria, 1090 Contact: Sonja Prager, Dr. +43 1 40400 ext 79470 sonja.prager@meduniwien.ac.at Principal Investigator: Sonja Prager, Dr. Sub-Investigator: Julia Hafner, Dr. Diabetes & Stoffwechselambulanz Gesundheitszentrum Wien Süd Recruiting Vienna, Austria, 1100 Contact: Helmut Brath, OA Dr. +43 1 60122 ext 4264 helmut.brath@wgkk.at Principal Investigator: Helmut Brath, OA Dr. 3. Med. Abtlg., KH Hietzing mit Neurologischem Zentrum Rosenhügel Recruiting Vienna, Austria, 1130 Contact: Rudolf Prager, Prof.Dr. +43 1 80110 ext 2351 rudolf.prager@wienkav.at Principal Investigator: Rudolf Prager, Prof.Dr. Sub-Investigator: Slobodan Peric, Dr. Zentrum für Klinische Studien Recruiting Wien, Austria, 1060 Contact: Ursula Hanusch, MD +43 1 266 21 91 dr.hanusch@dieinternistin.com Contact: Michaela Mauritz +43 1 266 21 91 office@dieinternistin.com Sub-Investigator: Marita Spak, MD Netherlands Maastricht University Medical Center; Dep. Cardiology Recruiting Maastricht, Netherlands, 6202 Contact: Hans-Peter Brunner-La Rocca, MD Prof +31 43-3877097 hp.brunnerlarocca@mumc.nl Contact: Mireille Spanjers +31 43-3877099 m.spanjers@mumc.nl Sub-Investigator: Nick Marks, MD Sub-Investigator: Wouter Robaeys, MD New Zealand Christchurch Heart Institute Recruiting Christchurch, New Zealand, 8140 Contact: Richard Troughton, MD Prof +64 3 364 1063 Richard.Troughton@cdhb.health.nz Contact: Lorraine Skelton +64 3 364 1063 lorraine.skelton@cdhb@health.nz Principal Investigator: Richard Troughton, MD Prof 收起 << |
NCT00295542 | Hypertension | Phase 4 | Completed | - | Spain ... 展开 >> Hospital Clinico Universitario Santiago de Compostela, Spain, 15706 收起 << |
NCT00741585 | Essential Hypertension ... 展开 >> Cardiovascular Disease Stroke Chronic Kidney Disease 收起 << | Phase 4 | Completed | - | Spain ... 展开 >> CS Friol Friol, Lugo, Spain, 27220 CS Baiona Baiona, Pontevedra, Spain, 36300 CS Bueu Bueu, Pontevedra, Spain, 36930 CS A Estrada La Estrada, Pontevedra, Spain, 26680 CS A Guarda La Guardia, Pontevedra, Spain, 36780 CS Valmiñor Nigran, Pontevedra, Spain, 36250 CS Panxón Nigrán, Pontevedra, Spain, 36340 CS Tomiño Tomiño, Pontevedra, Spain, 36200 Bioengineering & Chronobilogy Labs., University of Vigo Vigo, Pontevedra, Spain, 36200 Hospital do Meixoeiro Vigo, Pontevedra, Spain, 36200 CS Calle Cuba Vigo, Pontevedra, Spain, 36202 CS A Doblada Vigo, Pontevedra, Spain, 36205 CS Coia Vigo, Pontevedra, Spain, 36209 CS Sardoma Vigo, Pontevedra, Spain, 36214 CS Teis Vigo, Pontevedra, Spain, 36216 CS Vilaboa Vilaboa, Pontevedra, Spain, 36141 CS San Roque Vilagarcía De Arousa, Pontevedra, Spain, 36600 CS Fingoi Lugo, Spain, 27002 Complexo Hospitalario Universitario de Ourense Orense, Spain, 32005 CS Lerez Pontevedra, Spain, 36156 收起 << |
实验方案 | |||
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1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.11mL 0.42mL 0.21mL |
10.53mL 2.11mL 1.05mL |
21.05mL 4.21mL 2.11mL |
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