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SZL P1-41

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Chemical Structure| 222716-34-9 同义名 : -
CAS号 : 222716-34-9
货号 : A796427
分子式 : C24H24N2O3S
纯度 : 99%+
分子量 : 420.524
MDL号 : MFCD00711481
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 2 mg/mL(4.76 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 SZL P1-41, a specific inhibitor of Skp2, attaches to the F-box domain of Skp2, inhibiting the association with Skp1 and the formation of the Skp2 SCF complex. Similar to the effects of Skp2 deficiency, SZL P1-41 enhances apoptosis/senescence mediated by p27 and disrupts glycolysis driven by Akt. It exhibits anti-tumor activities. At concentrations ranging from 5 to 20μM over a period of 24 hours, it leads to the induction of endogenous p27 protein expression in PC3 cells. Additionally, it prompts the expression of p21, another substrate of Skp2.[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.38mL

0.48mL

0.24mL

11.89mL

2.38mL

1.19mL

23.78mL

4.76mL

2.38mL
参考文献

[1]Chan CH et al. Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression. Cell. 2013 Aug 1;154(3):556-68.