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LM22B-10

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Chemical Structure| 342777-54-2 同义名 : -
CAS号 : 342777-54-2
货号 : A796121
分子式 : C27H33ClN2O4
纯度 : 99%+
分子量 : 485.015
MDL号 : MFCD00483554
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 145 mg/mL(298.96 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 LM22B-10 is a TrkB/TrkC neurotrophic factor receptor activator that induces the activation of TrkB, TrkC, AKT, and ERK in vivo and in vitro. The maximum neurotrophic survival activity of LM22B-10 was higher than that of BDNF (53 ± 7.2% higher than BDNF at 0.7 nM) and NT-3 (91 ± 8.6% higher than NT-3 at 0.7 nM), with EC50 values of 200-300 nM. The pattern of Trk and downstream signalling activation induced by LM22B-10 was different from that of BDNF and NT-3. The mean neurite length induced by LM22B-10 (1,000 nM) was significantly larger, up to 40 µm. LM22B-10 (250-2000 nM) binds TrkB-Fc and TrkC-Fc in a dose-dependent manner. LM22B-10 inhibits the binding of BDNF to TrkB-expressing cells and the binding of NT-3 to TrkC-expressing cells. LM22B-10 promotes cell survival and acts preferentially on TrkB and TrkC. LM22B-10, but not BDNF or NT-3, promotes neuronal growth in an inhibitory environment. LM22B-10 also induces TrkB, TrkC, AKT and ERK activation in cultured hippocampal neurons[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.06mL

0.41mL

0.21mL

10.31mL

2.06mL

1.03mL

20.62mL

4.12mL

2.06mL
参考文献

[1]Yang T, et al. A small molecule TrkB/TrkC neurotrophin receptor co-activator with distinctive effects on neuronal survival and process outgrowth. Neuropharmacology. 2016 Nov;110(Pt A):343-61.