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AKR1C3-IN-1

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Chemical Structure| 327092-81-9 同义名 : CRT0036521
CAS号 : 327092-81-9
货号 : A795496
分子式 : C16H15NO4S
纯度 : 98%
分子量 : 317.36
MDL号 : MFCD01197550
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(330.85 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 AKR1C3-IN-1 has a weak activity of 20.3±3.8 μM against AKR1C1 and >30 μM against AKR1C2 and AKR1C4. The IC50 for AKR1C3-IN-1 to inhibit AKR1C3 activity (inhibition of PR-104H formation) is 0.027±0.002 μM[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.15mL

0.63mL

0.32mL

15.75mL

3.15mL

1.58mL

31.51mL

6.30mL

3.15mL
参考文献

[1]Jamieson SM, et al. 3-(3,4-Dihydroisoquinolin-2(1H)-ylsulfonyl)benzoic Acids: highly potent and selective inhibitors of the type 5 17-β-hydroxysteroid dehydrogenase AKR1C3. J Med Chem. 2012 Sep 13;55(17):7746-58.