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(±)-Vesamicol HCl

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Chemical Structure| 120447-62-3 同义名 : (±)-AH5183 hydrochloride;(±)-Vesamicol hydrochloride;AH-5183 hydrochloride, Vesamicol hydrochloride, (+/-)-
CAS号 : 120447-62-3
货号 : A793614
分子式 : C17H26ClNO
纯度 : 99%+
分子量 : 295.847
MDL号 : MFCD06804635
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 20 mg/mL(67.6 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 (±)-Vesamicol hydrochloride ((±)-AH5183 hydrochloride) acts as a potent inhibitor of vesicular acetylcholine transport with a Ki of 2 nM. It also demonstrates high affinity for σ1 and σ2 receptors, with Kis of 26 nM and 34 nM, respectively[1].[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.38mL

0.68mL

0.34mL

16.90mL

3.38mL

1.69mL

33.80mL

6.76mL

3.38mL
参考文献

[1]S M Efange, et al. N-hydroxyalkyl derivatives of 3 beta-phenyltropane and 1-methylspiro[1H-indoline-3,4'-piperidine]: vesamicol analogues with affinity for monoamine transporters. J Med Chem. 1997 Nov 21;40(24):3905-14.

[2]H Kobayashi, et al. Effects of systemic administration of 2-(4-phenyl-piperidino)-cyclohexanol (vesamicol) and an organophosphate DDVP on the cholinergic system in brain regions of rats. Brain Res Bull. 1997;43(1):17-23.