6-Thioinosine

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Chemical Structure| 574-25-4 同义名 : 6-​Thioinosine;6TI;6-Mercaptopurine riboside
CAS号 : 574-25-4
货号 : A792872
分子式 : C10H12N4O4S
纯度 : 95%
分子量 : 284.292
MDL号 : MFCD00005743
存储条件:

Pure form Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 85 mg/mL(298.99 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 6-Thioinosine (6TI) functions as a purine antimetabolite and serves as an anti-adipogenesis agent. It reduces mRNA levels of PPAR γ and C/EBPα, along with PPAR γ target proteins such as LPL, CD36, aP2, and LXRα[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.52mL

0.70mL

0.35mL

17.59mL

3.52mL

1.76mL

35.18mL

7.04mL

3.52mL

参考文献

[1]Lee J, et al. Anti-adipogenesis by 6-thioinosine is mediated by downregulation of PPAR gamma through JNK-dependent upregulation of iNOS. Cell Mol Life Sci. 2010 Feb;67(3):467-81.

[2]Neubert D, et al. Interference of 6-mercaptopurine riboside, 6-methylmercaptopurine riboside and azathioprine with the morphogenetic differentiation of mouse extremities in vivo and in organ culture. Naunyn Schmiedebergs Arch Pharmacol. 1977 Jun;298(2):93-105.