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TFAP

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Chemical Structure| 1011244-68-0 同义名 : N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide
CAS号 : 1011244-68-0
货号 : A790540
分子式 : C13H10F3N3O
纯度 : 99%+
分子量 : 281.233
MDL号 : MFCD12463359
存储条件：

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 150 mg/mL(533.37 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Biosynthesis of prostaglandins from arachidonic acid (AA) is catalyzed by cyclooxygenase (COX), which exists as COX-1 and COX-2. AA is in turn released from the cell membrane upon neopathological stimuli. COX inhibitors interfere in this catalytic and disease onset process[1]. TFAP is a selective COX-1 inhibitor with an IC50 value of 0.8 μM. Although TFAP shows potent analgesic effect without gastric damage, the urine after administration of TFAP becomes red-purple[2].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02238015 - Unknown March 2015 China, Zhejiang ... 展开 >> Wenzhou Medical University Recruiting WenZhou, Zhejiang, China, 325027 Contact: Qian Zheng, MD    18367839685    zq15.04@163.com 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.56mL

0.71mL

0.36mL

17.78mL

3.56mL

1.78mL

35.56mL

7.11mL

3.56mL
参考文献

[1]Vitale P, Panella A, Scilimati A, Perrone MG. COX-1 Inhibitors: Beyond Structure Toward Therapy. Med Res Rev. 2016;36(4):641‐671

[2]Kakuta H, Fukai R, Xiaoxia Z, et al. Identification of urine metabolites of TFAP, a cyclooxygenase-1 inhibitor. Bioorg Med Chem Lett. 2010;20(6):1840‐1843