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Mitochonic acid 5

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Chemical Structure| 1354707-41-7 同义名 : MA-5
CAS号 : 1354707-41-7
货号 : A788782
分子式 : C18H13F2NO3
纯度 : 99%+
分子量 : 329.298
MDL号 : MFCD31657404
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(318.86 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Mitochondrial dysfunction is involved in the pathogenesis of chronic kidney disease and acute kidney injury (AKI). Mitochonic acid 5 (MA-5) is a synthesized indole acetic acid derivative that facilitates ATP production, reduces the level of mitochondrial reactive oxygen species, and targets mitochondrial protein mitofilin. MA-5 binds to mitofilin with a Bmax value of 12.5±4.35ng and a Kd value of 28.2±11.4µM[1]. MA-5 at 1-10µM dose-dependently inhibited TNFα-induced apoptosis in mouse microglial BV-2 cells. Treatment with MA-5 at 5µM increased mitochondrial potential and decreased the level of mitochondrial calcium in TNFα-treated cells[2]. In a bilateral ischemia-reperfusion injury (IRI) model, oral administration of MA-5 at 25, 50, or 150mg/kg significantly improved plasma creatinine level after reperfusion compared to the vehicle-treated IRI mice. MA-5 treatment also significantly decreased the expression of AKI marker, KIM-1, at the outer medullar and the acute tubular necrosis score in IRI mice at 48h post-treatment. In a mouse model of cisplatin-induced nephropathy (CIN), MA-5 (50mg/kg)-treated mice showed significantly reduced plasma BUN 96h after cisplatin administration compared to the vehicle-treated CIN animals[1].
作用机制 Mitochonic acid 5 is a synthesized indole derivative that regulates mitochondrial ATP synthesis independently of electron transport chain and oxidative phosphorylation[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.04mL

0.61mL

0.30mL

15.18mL

3.04mL

1.52mL

30.37mL

6.07mL

3.04mL
参考文献

[1]Suzuki T, Yamaguchi H, Kikusato M, et al. Mitochonic Acid 5 Binds Mitochondria and Ameliorates Renal Tubular and Cardiac Myocyte Damage. J Am Soc Nephrol. 2016;27(7):1925-1932. doi:10.1681/ASN.2015060623

[2]Lei Q, Tan J, Yi S, Wu N, Wang Y, Wu H. Mitochonic acid 5 activates the MAPK-ERK-yap signaling pathways to protect mouse microglial BV-2 cells against TNFα-induced apoptosis via increased Bnip3-related mitophagy. Cell Mol Biol Lett. 2018;23:14.