产品说明书

5-R-Rivaroxaban

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Chemical Structure| 865479-71-6 同义名 : -
CAS号 : 865479-71-6
货号 : A785317
分子式 : C19H18ClN3O5S
纯度 : 99%
分子量 : 435.881
MDL号 : MFCD17171369
存储条件：

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 35 mg/mL(80.3 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Rivaroxaban (BAY 59-7939) is being developed as an oral, direct inhibitor of Factor Xa (FXa) for the prevention and treatment of both arterial and venous thrombosis. It competitively inhibits human FXa with a Ki of 0.4 nM, demonstrating over 10,000 times greater selectivity over other serine proteases and inhibits prothrombinase activity with an IC50 of 2.1 nM. In human and rabbit plasma, Rivaroxaban more potently inhibits endogenous FXa (IC50 21 nM) compared to rat plasma (IC50 290 nM). It effectively doubles prothrombin time and activates partial thromboplastin time at concentrations of 0.23 μM and 0.69 μM, respectively, indicating its anticoagulant effects[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.29mL

0.46mL

0.23mL

11.47mL

2.29mL

1.15mL

22.94mL

4.59mL

2.29mL
参考文献

[1]Roehrig S, et al. Discovery of the novel antithrombotic agent 5-chloro-N-({(5S)-2-oxo-3- [4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene- 2-carboxamide (BAY 59-7939): an oral, direct factor Xa inhibitor. J Med Chem. 2005 Sep 22;48(19)

[2]Perzborn E, et al. In vitro and in vivo studies of the novel antithrombotic agent BAY 59-7939--an oral, direct Factor Xa inhibitor. J Thromb Haemost. 2005 Mar;3(3):514-21.