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Byakangelicol

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Chemical Structure| 26091-79-2 同义名 : -
CAS号 : 26091-79-2
货号 : A782383
分子式 : C17H16O6
纯度 : 99%+
分子量 : 316.305
MDL号 : MFCD06796689
存储条件：

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(158.08 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Byakangelicol is isolated from the roots of Angelica dahurica with hepatoprotective activities. Byakangelicol (10-50 mM) concentration-dependently attenuated IL-1beta-induced COX-2 expression and PGE2 release. Byakangelicol inhibits IL-1beta-induced PGE2 release in A549 cells[1]. Byakangelicol and rivulobirin A may inhibit P-gp expressed at the BBB (blood-brain barrier) even under in vivo conditions[2]. The main biotransformation product, byakangelicin, showed inhibitory activities of NO production with the IC50 value of 217.83 μM, whereas the parent compound phellopterin showed cytotoxic effect on RAW264.7 cell at the concentration from 40 to 400 μM[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.16mL

0.63mL

0.32mL

15.81mL

3.16mL

1.58mL

31.62mL

6.32mL

3.16mL
参考文献

[1]Lin CH, Chang CW, Wang CC, Chang MS, Yang LL. Byakangelicol, isolated from Angelica dahurica, inhibits both the activity and induction of cyclooxygenase-2 in human pulmonary epithelial cells. J Pharm Pharmacol. 2002 Sep;54(9):1271-8

[2]Iwanaga K, Yoneda S, Hamahata Y, Miyazaki M, Shibano M, Taniguchi M, Baba K, Kakemi M. Inhibitory effects of furanocoumarin derivatives in Kampo extract medicines on P-glycoprotein at the blood-brain barrier. Biol Pharm Bull. 2011;34(8):1246-51

[3]Zhao AH, Yang XB, Yang XW, Zhang YB, Xu W, Liu JX. Biotransformation products of phellopterin by rat liver microsomes and the inhibition on NO production in LPS-activated RAW264.7 cells. J Asian Nat Prod Res. 2012;14(10):956-65